English Version

研究業績

2024

Nagase M, Ando H, Beppu Y, Kurihara H, Oki S, Kubo F, Yamamoto K, Nagase T, Kaname S, Akimoto Y, Fukuhara H, Sakai T, Hirose S, Nakamura N.
Glomerular Endothelial Cell Receptor ADGRF5 and the Integrity of the Glomerular Filtration Barrier.
J. Am. Soc. Nephrol. 2024 (PMID: 38844335)

2021

Matsumoto H, Miyagi H, Nakamura N, Shiga Y, Ohta T, Fujiwara S, Tsuzuki M.
Carbonic anhydrase inhibitor induces otic hair cell apoptosis via an intrinsic pathway and ER stress in zebrafish larvae.
Toxicol. Rep. 8, 1937-1947, 2021 (PMID: 34926172)

Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourao A, Klepac K, Buhler L, Alfaro AJ, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Muller TD, Kessler K, Schoneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer AFH, Sattler M, Bluher M, Herzig S
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Nat. Commun. 12, 2999, 2021 (PMID: 34016966)

Nakamura N
Cigarette smoke attenuates p300‐mediated Nrf2 acetylation in macrophages: Is stabilizing Nrf2 enough to halt COPD progression?
Respirology. 26, 19-20, 2021 (PMID: 32696525 )

2020

Ito D, Kawamura H, Oikawa A, Ihara Y, Shibata T, Nakamura N, Asano T, Kawabata S, Suzuki T, Masuda S
ppGpp functions as an alarmone in metazoa.
Commun. Biol. 3, 671, 2020 (PMID: 33188280)

2019

Kubo F, Ariestanti DM, Oki S, Fukuzawa T, Demizu R, Sato T, Sabirin RM, Hirose S, Nakamura N
Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells.
Respir. Res. 20, 11, 2019 (PMID: 30654796)

2018

Nakamura N
Ubiquitin system.
Int. J. Mol. Sci. 19, E1080, 2018 (PMID: 29617326)

2017

Matsumoto H, Fujiwara S, Miyagi H, Nakamura N, Shiga Y, Ohta T, Tsuzuki M.
Carbonic anhydrase inhibitors induce developmental toxicity during zebrafish embryogenesis, especially in inner ear.
Mar. Biotechnol. 19, 430-440, 2017 (PMID: 28695384)

2016

Harada K, Kato M, Nakamura N.
USP19-mediated deubiquitination facilitates the stabilization of HRD1 ubiquitin ligase.
Int. J. Mol. Sci. 17, 1829, 2016 (PMID: 27827840)

Miyagi H, Nag K, Sultana N, Munakata K, Hirose S, Nakamura N.
Characterization of the zebrafish cx36.7 gene promoter: its regulation of cardiac-specific expression and skeletal muscle-specific repression.
Gene 577, 265-274, 2016 (PMID: 26692140)

2015

Ariestanti DM, Ando H, Hirose S, Nakamura N.
Targeted disruption of Ig-Hepta/Gpr116 causes emphysema-like symptoms that are associated with alveolar macrophage activation.
J. Biol. Chem. 290, 11032-11040, 2015 (PMID: 25778400)

Nag K, Sultana N, Kato A, Dranik A, Nakamura N, Kutsuzawa K, Hirose S, Akaike T.
Ligand-induced internalization, recycling, and resensitization of adrenomedullin receptors depend not on CLR or RAMP alone but on the receptor complex as a whole.
Gen. Comp. Endocrinol. 212, 156-162, 2015 (PMID: 24815888)

2014

Nakamura N, Harada K, Kato M, Hirose S.
Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6.
Exp. Cell Res. 328(1), 207-216, 2014 (PMID: 25088257)

Sultana N, Nakamura N, Hirose S, Kutsuzawa K, Akaike T, Nag K.
Congenital heart disease and biotechnology: Connecting by connexin.
Adv. Mater. Res. 995, 85-112, 2014

Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Promel S, Ressl S, Schioth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X.
New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.
Ann. N.Y. Acad. Sci. 1333, 43-64, 2014 (PMID: 25424900)

2013

Nakamura N.
Ubiquitination regulates the morphogenesis and function of sperm organelles.
Cells 2(4), 732-750, 2013 (PMID: 24709878), (doi:10.3390/cells2040732)

Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S.
Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D.
PLOS One 8(7), e69451, 2013 (PMID: 23922714)

Ito Y, Kobayashi S, Nakamura N, Esaki M, Miyagi H, Hoshijima K, Hirose S.
Close association of carbonic anhydrase (CA2a & CA15a), Na+/H+ exchanger (Nhe3b), and ammonia transporter Rhcg1 in zebrafish ionocytes responsible for Na+ uptake.
Front. Physiol. 4, Article 59, 2013 (PMID: 23565095)

Fukuda H, Hirata T, Nakamura N, Kato A, Kawahara K, Wakabayashi S, Chang MH, Romero MF, Hirose S.
Identification and properties of a novel variant of Na+/HCO3- cotransporter 4 (NBC4) predominantly expressed in choroid plexus.
Biochem. J. 450(1), 179-187, 2013 (PMID: 23205667)

Zhao B, Ito K, Iyengar PV, Hirose S, Nakamura N.
MARCH7 E3 ubiquitin ligase is highly expressed in developing spermatids of rats and its possible involvement in head and tail formation.
Histochem. Cell Biol. 139(3), 447-460, 2013 (PMID: 23104140)

2012

Han SO, Xiao K, Kim J, Wu JH, Wisler JW, Nakamura N, Freedman NJ, Shenoy SK.
MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β2-adrenergic receptors.
J. Cell Biol. 199(5), 817-830, 2012 (PMID: 23166351)

Yogo K, Tojima H, Ohno JY, Ogawa T, Nakamura N, Hirose S, Takeya T, Kohsaka T.
Identification of SAMT family proteins as substrates of MARCH11 in mouse spermatids.
Histochem. Cell Biol. 137(1), 53-65, 2012 (PMID: 22075566)

2011

Nakamura N.
The role of the transmembrane RING finger proteins in cellular and organelle function.
Membranes 1(4), 354-393, 2011 (the Special issue Biological Membrane Morphogenesis) (PMID: 24957874), (doi:10.3390/membranes1040354)

Iyengar PV, Hirota T, Hirose S, Nakamura N.
Membrane-associated RING-CH 10 (MARCH10 Protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella.
J. Biol. Chem. 286(45), 39082-39090, 2011 (PMID: 21937444)

2010

Saito K, Nakamura N, Ito Y, Hoshijima K, Esaki M, Zhao B, Hirose S.
Identification of zebrafish FXYD11a protein that is highly expressed in ion-transporting epithelium of the gill and skin and its possible role in ion homeostasis.
Front. Physiol. 1, 129, 2010 (PMID: 21423371)

Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S.
Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.
J. Biol. Chem. 285 (4), 2653-2664, 2010 (PMID: 19926789)

2009-1998

Esaki M, Hoshijima K, Nakamura N, Munakata K, Tanaka M, Ookata K, Asakawa K, Kawakami K, Wang W, Weinberg ES, Hirose S.
Mechanism of development of ionocytes rich in vacuolar-type H+-ATPase in the skin of zebrafish larvae.
Dev. Biol. 329(1), 116-129, 2009 (PMID: 19268451)

Aihara T, Nakamura N, Honda S, Hirose S.
A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis of mice.
Biol. Reprod. 80(4), 762-770, 2009 (PMID: 19208545)
(This work was chosen for a 2009-2010 Biology of Reproduction Calendar)

Nakamura N, Hirose S.
Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane.
Mol. Biol. Cell 19(5), 1903-1911. 2008 (PMID: 18287522)

Morokuma Y, Nakamura N, Kato A, Notoya M, Yamamoto Y, Sakai Y, Fukuda H, Yamashina S, Hirata Y, Hirose S.
MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids.
J. Biol. Chem. 282 (34), 24806-24815. 2007 (PMID: 17604280)

Nakamura N, Kimura Y, Tokuda M, Honda S, Hirose S.
MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology.
EMBO Rep. 7 (10), 1019-1022. 2006. Cover Caption (PMID: 16936636)

Tateno T, Nakamura N, Hirata Y, Hirose S.
Role of C-terminus of Kir7.1 potassium channel in cell-surface expression.
Cell Biol. Int. 30 (3), 270-277. 2006 (PMID: 16406822)

Fukuda H, Nakamura N, Hirose S.
MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II.
J. Biochem. 139 (1), 137-145. 2006 (PMID: 16428329) (Full Text)

Nakamura N, Fukuda H, Kato A, Hirose S.
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.
Mol. Biol. Cell 16 (4), 1696-1710. 2005 (PMID: 15689499)

Suzuki Y, Yasuoka Y, Shimohama T, Nishikitani M, Nakamura N, Hirose S, Kawahara K.
Expression of the K+ channel Kir7.1 in the developing rat kidney: Role in K+ excretion.
Kidney Int. 63(3), 969-975. 2003 (PMID: 12631077)

Miyamoto K, Nakamura N, Kashiwagi M, Honda S, Kato A, Hasegawa S, Takei Y, Hirose S.
RBCC protein expression in branchial epithelial cells of Japanese eel.
Eur. J. Biochem. 269(24), 6152-6161. 2002 (PMID: 12473111)

Nakamura N, Suzuki Y, Ikeda Y, Notoya M, Hirose S.
Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1.
J. Biol. Chem. 275, 28276-28284. 2000 (PMID: 10871613)

Ookata K, Tojo A, Suzuki Y, Nakamura N, Kimura K, Wilcox CS, Hirose S.
Localization of inward rectifier potassium channel Kir7.1 in the basal membrane of distal nephron.
J. Am. Soc. Nephrol. 11, 1987-1994. 2000 (PMID: 11053473)

Nakamura N, Suzuki Y, Sakuta H, Ookata K, Kawahara K, Hirose S.
Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase.
In Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels (Suketa, Y., Carafoli, E., Lazdunski, M., Mikoshiba, K., Okada, Y., and Wright, E.M., eds), pp. 39-40, Elsevier Science, Amsterdam, 2000

Nakamura N, Suzuki Y, Sakuta H, Ookata K, Kawahara K, Hirose S.
Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase.
Biochem. J. 342, 329-336. 1999 (PMID: 10455019)

Suzuki Y, Itakura M, Kashiwagi M, Nakamura N, Matsuki T, Sakuta H, Naito N, Takano K, Fujita T, Hirose S.
Identification by differential display of a hypertonicity-inducible inward rectifier potassium channel highly expressed in chloride cells.
J. Biol. Chem. 274, 11376-11382. 1999 (PMID: 10196230)

Suzuki Y, Nakamura N, Sakuta H, Takano K, Fujita T, Hirose S.
Cloning and properties of a hypertonicity-inducible inward rectifier K+ channel from euryhaline eels.
In: Cell Volume Regulation. Y. Okada, ed. (Amsterdam: Elsevier Science), 1998


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